A New and Convenient One-StepSynthesis of the Natural 3-Deoxyantho­cyanidins Apigeninidinand Luteolinidin Chlorides from 2,4,6-Triacetoxy­benzaldehyde

Abstract

The total synthesis of apigeninidin (1),luteolinidin (2) and 5,7-dihydroxyflavylium(5) chlorides is performed through a onestep reaction from an acetylated derivative of a commercial reagent.Condensation reaction between 2,4,6-triacetoxybenzaldehyde and anacetophenone derivative in anhyd methanolic hydrogen chloride providesthe 3-deoxyanthocyanidins in high yields.

Key words

total synthesis - natural products - heterocycles - polycycles - phenols

References

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1

Present address: Departamento de QuímicaOrgánica I, Facultad de Ciencias Químicas, UniversidadComplutense, 28040 Madrid, Spain, Fax: [phone].